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雑誌文献

循環器ジャーナル68巻4号

2020年10月発行

文献概要

特集 抗血栓療法—日常臨床での疑問に応える Ⅱ.虚血性心疾患・下肢動脈疾患に対する抗血栓療法

心房細動合併冠動脈疾患患者の抗血栓療法の注意点は?

著者: 古島知樹1 安田聡2

所属機関: 1高知大学医学部老年病・循環器内科学 2東北大学大学院循環器内科学

ページ範囲:P.618 - P.623

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・心房細動を合併したPCI施行患者およびACS患者に対する急性期の抗血栓療法は,抗凝固薬(ワルファリンよりDOACが優先される)+P2Y12受容体拮抗薬の2剤併用が基本である.
・心房細動合併冠動脈疾患患者に対する慢性安定期の抗血栓療法は抗凝固薬単剤が推奨される.

参考文献

1) Kirchhof P, Ammentorp B, Darius H, et al:Management of atrial fibrillation in seven European countries after the publication of the 2010 ESC Guidelines on atrial fibrillation:primary results of the PREvention oF thromboemolic events--European Registry in Atrial Fibrillation(PREFER in AF). Europace 16:6-14, 2014
2) Akao M, Chun YH, Wada H, et al:Current status of clinical background of patients with atrial fibrillation in a community-based survey:the Fushimi AF Registry. J Cardiol 61:260-266, 2013
3) Connolly S, Pogue J, Hart R, et al:Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events(ACTIVE W):a randomised controlled trial. Lancet 367:1903-1912, 2006
4) Dewilde WJ, Oirbans T, Verheugt FW, et al:Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention:an open-label, randomised, controlled trial. Lancet 381:1107-1115, 2013
5) Gibson CM, Mehran R, Bode C, et al:Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI. N Engl J Med 375:2423-2434, 2016
6) Cannon CP, Bhatt DL, Oldgren J, et al:Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation. N Engl J Med 377:1513-1524, 2017
7) Lopes RD, Heizer G, Aronson R, et al:Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation. N Engl J Med 380:1509-1524, 2019
8) Vranckx P, Valgimigli M, Eckardt L, et al:Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation(ENTRUST-AF PCI):a randomised, open-label, phase 3b trial. Lancet 394:1335-1343, 2019
9) Khan SU, Osman M, Khan MU, et al:Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Intervention:A Systematic Review and Meta-analysis. Ann Intern Med 172:474-483, 2020
10) Gargiulo G, Goette A, Tijssen J, et al:Safety and efficacy outcomes of double vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention:a systematic review and meta-analysis of non-vitamin K antagonist oral anticoagulant-based randomized clinical trials. Eur Heart J 40:3757-3767, 2019
11) 日本循環器学会:2020年JCSガイドラインフォーカスアップデート版 冠動脈疾患患者における抗血栓療法.2020 https://www.j-circ.or.jp/cms/wp-content/uploads/2020/04/JCS2020_Kimura_Nakamura.pdf
12) Lopes RD, Hong H, Harskamp RE, et al:Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention:A Network Meta-analysis of Randomized Controlled Trials. JAMA Cardiol 4:747-755, 2019
13) Matsumura-Nakano Y, Shizuta S, Komasa A, et al:Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation. Circulation 139:604-616, 2019
14) Yasuda S, Kaikita K, Akao M, et al:Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease. N Engl J Med 381:1103-1113, 2019

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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