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雑誌文献

循環器ジャーナル69巻3号

2021年07月発行

文献概要

特集 成人先天性心疾患 エキスパートコンセンサス Ⅱ.成人先天性心疾患特有の問題点に対するアプローチ

成人期Fontan術後患者の問題点,PLE

著者: 杜徳尚12

所属機関: 1岡山大学循環器内科 2岡山大学病院成人先天性心疾患センター

ページ範囲:P.370 - P.377

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・Fontan手術は低酸素血症の改善を目指す手術であるが,特殊な血行動態により遠隔期の合併症は少なくない.
・Fontan術後には不整脈,体心室機能低下,肺血管抵抗の上昇,といった循環器合併症だけでなく,血栓塞栓症,肝・腎機能異常や蛋白漏出性胃腸症など全身臓器に注意して診療する.

参考文献

1) Gewillig M:The Fontan circulation. Heart 91:839-846, 2005
2) Fontan F, Baudet E:Surgical repair of tricuspid atresia. Thorax 26:240-248, 1971
3) Rychik J, Atz AM, Celermajer DS, et al;American Heart Association Council on Cardiovascular Disease in the Young and Council on Cardiovascular and Stroke Nursing:Evaluation and Management of the Child and Adult With Fontan Circulation:A Scientific Statement From the American Heart Association. Circulation 140:e234-e284, 2019
4) Diller GP, Giardini A, Dimopoulos K, et al:Predictors of morbidity and mortality in contemporary Fontan patients:results from a multicenter study including cardiopulmonary exercise testing in 321 patients. Eur Heart J 31:3073-3083, 2010
5) Quinton E, Nightingale P, Hudsmith L, et al:Prevalence of atrial tachyarrhythmia in adults after Fontan operation. Heart 101:1672-1677, 2015
6) Ohuchi H, Hasegawa S, Yasuda K, et al:Severely impaired cardiac autonomic nervous activity after the Fontan operation. Circulation 104:1513-1518, 2001
7) de Groot NM, Lukac P, Blom NA, et al:Long-term outcome of ablative therapy of postoperative supraventricular tachycardias in patients with univentricular heart:a European multicenter study. Circ Arrhythm Electrophysiol 2:242-248, 2009
8) Anderson PA, Sleeper LA, Mahony L, et al;Pediatric Heart Network Investigators:Contemporary outcomes after the Fontan procedure:a Pediatric Heart Network multicenter study. J Am Coll Cardiol 52:85-98, 2008
9) Shaddy RE, Boucek MM, Hsu DT, et al;Pediatric Carvedilol Study Group:Carvedilol for children and adolescents with heart failure:a randomized controlled trial. JAMA 298:1171-1179, 2007
10) Yamagishi M, Kurosawa H, Hashimoto K, et al:The role of plasma endothelin in the Fontan circulation. J Cardiovasc Surg(Torino)43:793-797, 2002. PMID:12483168.
11) Zongtao Y, Huishan W, Zengwei W, et al:Experimental study of nonpulsatile flow perfusion and structural remodeling of pulmonary microcirculation vessels. Thorac Cardiovasc Surg 58:468-472, 2010
12) Egbe AC, Connolly HM, Niaz T, et al:Prevalence and outcome of thrombotic and embolic complications in adults after Fontan operation. Am Heart J 183:10-17, 2017
13) Monagle P, Cochrane A, Roberts R, et al;Fontan Anticoagulation Study Group. A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children. J Am Coll Cardiol 58:645-651, 2011
14) McCrindle BW, Manlhiot C, Cochrane A, et al;Fontan Anticoagulation Study Group. Factors associated with thrombotic complications after the Fontan procedure:a secondary analysis of a multicenter, randomized trial of primary thromboprophylaxis for 2 years after the Fontan procedure. J Am Coll Cardiol 61:346-353, 2013
15) Pujol C, Müssigmann M, Schiele S, et al:Direct oral anticoagulants in adults with congenital heart disease-a single centre study. Int J Cardiol 300:127-131, 2020
16) Kawamatsu N, Ishizu T, Machino-Ohtsuka T, et al:Direct oral anticoagulant use and outcomes in adult patients with Fontan circulation:A multicenter retrospective cohort study. Int J Cardiol 327:74-79, 2021
17) van Nieuwenhuizen RC, Peters M, Lubbers LJ, et al:Abnormalities in liver function and coagulation profile following the Fontan procedure. Heart 82:40-46, 1999
18) Egbe AC, Poterucha JT, Warnes CA, et al:Hepatocellular Carcinoma After Fontan Operation:Multicenter Case Series. Circulation 138:746-748, 2018
19) Sharma S, Ruebner RL, Furth SL, et al:Assessment of Kidney Function in Survivors Following Fontan Palliation. Congenit Heart Dis 11:630-636, 2016
20) Dimopoulos K, Diller GP, Koltsida E, et al:Prevalence, predictors, and prognostic value of renal dysfunction in adults with congenital heart disease. Circulation 117:2320-2328, 2008
21) Mertens L, Hagler DJ, Sauer U, et al:Protein-losing enteropathy after the Fontan operation:an international multicenter study. PLE study group. J Thorac Cardiovasc Surg 115:1063-1073, 1998
22) John AS, Johnson JA, Khan M, et al:Clinical outcomes and improved survival in patients with protein-losing enteropathy after the Fontan operation. J Am Coll Cardiol 64:54-62, 2014

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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