循環器ジャーナル69巻4号

2021年10月発行

特集 プレシジョン・メディシン時代における腫瘍循環器学の重要性 Ⅳ章　腫瘍循環器学　トピックス

クローン性造血（CHIP）と腫瘍循環器学

著者： 福本義弘¹

所属機関： ¹久留米大学医学部内科学講座心臓・血管内科部門

ページ範囲：P.634 - P.640

Point
・CHIPは造血器腫瘍発症のリスクを上げるが，必ずしも造血器腫瘍を発症するわけではない．
・CHIPはIL-1βやIL-6を介して動脈硬化，心不全，血栓症などの発症リスクを上げる．
・CHIPのうち，高頻度で認められるのがDNMT3A，TET2，ASXL1，JAK2である．

参考文献

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