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循環器ジャーナル70巻2号

2022年04月発行

文献概要

特集 循環器薬の使い方—使い分け,モニタリング,導入・中止のタイミング Ⅲ章 不整脈

抗凝固薬の使い方

著者: 赤尾昌治1

所属機関: 1国立病院機構京都医療センター循環器内科

ページ範囲:P.292 - P.299

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・経口抗凝固薬は,ワルファリンから,2011年以降に登場したDOACに世代交代した.
・DOACは頻繁なモニタリングも不要で,固定用量で用いることができるが,添付文書に則った用量選択を遵守する.
・出血性副作用に注意が必要で,出血の予防と,出血時の迅速かつ的確な対処が重要である.

参考文献

1)日本循環器学会,日本不整脈心電学会:2020年改訂版 不整脈薬物治療ガイドライン.2020
2)Petersen P, Boysen G, Godtfredsen J, et al : Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study. Lancet 333 : 175-179, 1989
3)Stroke Prevention in Atrial Fibrillation Investigators : Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation 84 : 527-539, 1991
4)Connolly SJ, Ezekowitz MD, Yusuf S, et al : Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361 : 1139-1151, 2009
5)Patel MR, Mahaffey KW, Garg J, et al : Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 365 : 883-891, 2011
6)Granger CB, Alexander JH, McMurray JJ, et al : Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365 : 981-992, 2011
7)Giugliano RP, Ruff CT, Braunwald E, et al : Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 369 : 2093-2104, 2013
8)Ruff CT, Giugliano RP, Braunwald E, et al : Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation : a meta-analysis of randomised trials. Lancet 383 : 955-962, 2014
9)Abe M, Ogawa H, Ishii M, et al : Relation of stroke and major bleeding to creatinine clearance in patients with atrial fibrillation(from the Fushimi AF Registry). Am J Cardiol 119 : 1229-1237, 2017
10)Douketis JD, Spyropoulos AC, Kaatz S, et al : Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation. N Engl J Med 373 : 823-833, 2015
11)Yasuda S, Kaikita K, Akao M, et al : Antithrombotic therapy for atrial fibrillation with stable coronary disease. N Engl J Med 381 : 1103-1113, 2019
12)Piccini JP, Hellkamp AS, Washam JB, et al : Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation. Circulation 133 : 352-360, 2016
13)Jaspers Focks J, Brouwer MA, Wojdyla DM, et al : Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation : post hoc analysis of the ARISTOTLE trial. BMJ 353 : i2868, 2016
14)Ruff CT, Giugliano RP, Antman EM : Management of Bleeding With Non-Vitamin K Antagonist Oral Anticoagulants in the Era of Specific Reversal Agents. Circulation 134 : 248-261, 2016
15)Akao M, Chun Y, Wada H, et al : Current status of clinical background of patients with atrial fibrillation in a community-based survey : The Fushimi AF Registry. J Cardiol 61 : 260-266, 2013
16)Akao M, Chun YH, Esato M, et al : Inappropriate use of oral anticoagulants for patients with atrial fibrillation. Circ J 78 : 2166-2172, 2014
17)Okumura K, Akao M, Yoshida T, et al : Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med 383 : 1735-1745, 2020

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:2432-3292

印刷版ISSN:2432-3284

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