臨床検査49巻1号

2005年01月発行

今月の主題 ミトコンドリア病 総論

体細胞ミトコンドリアゲノム遺伝情報の維持

著者： 康東天¹

所属機関： ¹九州大学大学院医学研究院臨床検査医学

ページ範囲：P.16 - P.24

〔SUMMARY〕　ミトコンドリアDNA遺伝情報は好気的ATP合成に必須であり，それゆえその遺伝情報の維持は細胞が正常に機能し生存していくうえで必須である．しかしミトコンドリアは好気的ATP産生に伴う膨大な酸素消費に伴い，大量の活性酸素を産生しており非常に強い酸化ストレス下にある．その結果ミトコンドリアDNAは核DNAより強い酸化障害を受けており，体細胞における変異率が核DNAよりはるかに高いことが近年実証され，現在，その変異が加齢に伴う多くの病態に関与していると考えられるようになっている．〔臨床検査　49：16-24，2005〕

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