臨床検査50巻10号

2006年10月発行

今月の主題 認知症の動的神経病理 各論

アルファシヌクレイノパチー

著者： 髙尾昌樹¹²³

所属機関： ¹慶應義塾大学医学部法医学教室 ²財団法人脳血管研究所美原記念病院神経内科 ³

ページ範囲：P.1130 - P.1136

　アルファシヌクレイン(α-synuclein)が，主に中枢神経系の神経細胞やグリア細胞に異常に蓄積し，臨床的に何らかの神経症状を生じる疾患あるいは状態をアルファシヌクレイノパチーと呼び，Parkinson病(PD)，認知症を伴うLewy小体病(DLB)，多系統萎縮症(MSA)などが含まれる．神経病理学的にPD，DLBはLewy小体，Lewy neuritesを，MSAではグリア細胞内のglial cytoplasmic inclusionsを中核とする．〔臨床検査　50：1130-1136，2006〕

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