臨床検査50巻5号

2006年05月発行

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今月の主題 腎疾患と臨床検査 話題

腎臓線維化と低酸素-HIF

著者： 孫大輔¹ 南学正臣

所属機関： ¹東京大学医学部附属病院・腎臓内分泌内科

ページ範囲：P.571 - P.574

1．はじめに

　慢性腎不全患者が末期腎不全に至る原因として，従来，糸球体高血圧や蛋白尿などが重視されてきたが，近年「低酸素」という病態が注目されてきている．糖尿病性腎症や高血圧性腎硬化症など，腎不全の原因が異なっていても，ある閾値を超えると腎不全は不可逆的に進行していくが，その共通の病態は「final common pathway」と呼ばれ，低酸素がその中心をなすと考えられている．ここでは，低酸素が腎不全の進行にどのように影響を及ぼすのかを，腎線維化との関係を中心に解説する．

参考文献

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