臨床検査51巻10号

2007年10月発行

今月の主題 白血球 各論

血管炎の病態と好中球

著者： 鈴木和男¹²

所属機関： ¹千葉大学大学院医学研究院免疫発生学炎症制御学 ²国立感染症研究所

ページ範囲：P.1071 - P.1080

　好中球は，活性酸素産生やmyeloperoxidase(MPO)が産生するOCl^－によって感染防御にはたらく．しかし，血管炎患者血清中に上昇する自己抗体MPO-ANCAおよびMPOが発症に関与していることがMPOノックアウトマウスによって証明された．また，MPOの重鎖のNおよびC末端にエピトープをもつMPO-ANCAが病態の重症化と関連することが判明した．一方，急性進行性糸球体腎炎(RPGN)を自然発症する病態モデルSCG/Kjマウスや真菌分子C. albicans extract(CADS)，C. albicans water soluble glycoprotein(CAWS)誘導の冠状動脈炎を誘発するマウスの解析から治療方法が検討されている．最近，MPO抗体が糸球体内皮細胞に直接反応してICAM-1発現を誘発することがわかったことから，in vivoでのMPO抗体の役割を知るために量子ドットを使ったトレーザ解析法が有用となってきている．

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