臨床検査51巻9号

2007年09月発行

今月の主題 フローサイトメトリー 臨床・研究への応用

キメリズム

著者： 渡辺信和¹ 高橋聡²

所属機関： ¹東京大学医科学研究所FACSコアラボラトリー ²東京大学医科学研究所附属病院内科

ページ範囲：P.977 - P.982

　HLAの血清学タイピングに使用する目的で作製された抗HLAモノクローナル抗体が，フローサイトメトリーでも利用可能であることがわかり，ミスマッチHLAをマーカーとした同種移植後のキメリズム解析法が考案された．本キメリズム解析法(HLA-FACS法)には，フローサイトメトリーのもつ多くの利点が生かされており，HLAミスマッチ移植後の様々な病態の診断やメカニズムの解明に極めて有力な手段となる可能性がある．

参考文献

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