臨床検査52巻11号

2008年10月発行

特集 ホルモンの病態異常と臨床検査 各論Ⅰ　ホルモンの病態異常と検査 1．下垂体前葉

3) TSH

著者： 渋沢信行¹ 山田正信¹

所属機関： ¹群馬大学大学院医学系研究科病態制御内科

ページ範囲：P.1189 - P.1192

　甲状腺刺激ホルモン(thyroid-stimulating hormone, thyrotropin；TSH)は下垂体前葉で合成・分泌され，甲状腺機能を調節する糖蛋白質ホルモンである．TSH合成・分泌は視床下部ホルモンであるTSH放出ホルモン(TSH releasing hormone；TRH)により促進される一方，甲状腺ホルモン(主にT₃)により抑制される．血中TSH濃度はこの視床下部-下垂体-甲状腺系の生理的フィードバック機構により変化するため，生体において甲状腺機能を反映する最も鋭敏なマーカーである．

参考文献

1) Cohen RN, Wondisford FE：Chemistry and biosynthesis of thyrotropin. In：Werner ＆ Ingbar's the Thyroid A fundamental and clinical text 9th ed. (Braverman LE, Utiger RD, ed), Lippincott Williams ＆ Wilkins, Philadelphia, pp159-175, 2005

2) Yamada M, Saga Y, Shibusawa N, et al：Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci USA　94：10862-10867, 1997

3) Beck-Peccoz P, Amr S, Menezes-Ferreira MM, et al：Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism. Effect of treatment with thyrotropin-releasing hormone. N Engl J Med　312：1085-1090, 1985

4) Papandreou MJ, Persani L, Asteria C, et al：Variable carbohydrate structures of circulating thyrotropin as studied by lectin affinity chromatography in different clinical conditions. J Clin Endocrinol Metab　77：393-398, 1993

5) Lazar MA：Thyroid hormone receptors：multiple forms, multiple possibilities. Endocr Rev　14：184-193, 1993

6) Shibusawa N, Hollenberg AN, Wondisford FE：Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem　278：732-738, 2003

7) Ferland L, Labrie F, Jobin M, et al：Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion. Biochem Biophys Res Commun　68：149-156, 1976

8) Hollenberg AN：Regulation of thyrotropin secretion. In：Werner ＆ Ingbar's the Thyroid A fundamental and clinical text 9th ed (Braverman LE, Utiger RD, eds), Lippincott Williams ＆ Wilkins, Philadelphia, pp197-213, 2005

9) Scanlon MF, Weightman DR, Shale DJ, et al：Dopamine is a physiological regulator of thyrotrophin(TSH) secretion in normal man. Clin Endocrinol(Oxf)　10：7-15, 1979

10) Samuels MH, Luther M, Henry P, et al：Effects of hydrocortisone on pulsatile pituitary glycoprotein secretion. J Clin Endocrinol Metab　78：211-215, 1994

11) Spaulding SW：Biological actions of thyrotropin. In：Werner ＆ Ingbar's the Thyroid A fundamental and clinical text 9th ed(Braverman LE, Utiger RD, eds), Lippincott Williams ＆ Wilkins, Philadelphia, pp183-197, 2005

12) Surks MI, Goswami G, Daniels GH：The thyrotropin reference range should remain unchanged. J Clin Endocrinol Metab　90：5489-5496, 2005

13) Surks MI, Hollowell JG：Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population：implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab　92：4575-4582, 2007

14) Koliakos G, Gaitatzi M, Grammaticos P：Stability of serum TSH concentration after non refrigerated storage. Minerva Endocrinol　24：113-115, 1999

15) 森昌朋：TSH産生腫瘍．日内会誌　83：2075-2079，1994

16) Shibusawa N, Yamada M, Hirato J, et al：Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs：ontogeny study of congenital tertiary hypothyroidism in mice. Mol Endocrinol　14：137-146, 2000