臨床検査52巻11号

2008年10月発行

特集 ホルモンの病態異常と臨床検査 各論Ⅰ　ホルモンの病態異常と検査 8．生殖関連

4) インヒビン/アクチビン

著者： 安部由美子¹ 宮本薫²

所属機関： ¹群馬大学医学部保健学科基礎検査学 ²福井大学医学部分子生体情報学

ページ範囲：P.1276 - P.1280

はじめに

　インヒビンとアクチビンは，卵胞刺激ホルモン(follicle-stimulating hormone；FSH)分泌調節因子として卵巣から単離されたホルモン/増殖因子である．1932年にMcCullaghは下垂体の去勢細胞の出現を抑制する精巣由来の水溶性ホルモンをインヒビンと呼ぶことを提唱した¹⁾．その後，卵胞液中にもインヒビン様物質の存在することが報告され，1985年にFSH分泌抑制物質としてインヒビンが²⁾，翌1986年にFSH分泌促進物質としてアクチビンが単離同定された．その後，アクチビンレセプターが同定され，下垂体以外の組織においても細胞の増殖や分化の調節をはじめとする様々な作用を発揮する増殖因子であることが明らかにされている．

参考文献

1) McCullagh DR：Dual endocrine activity of the testes. Science　76：19020, 1932

2) Miyamoto K, Hasegawa Y, Fukuda M, et al：Isolation of porcine follicular fluid inhibin of 32k daltons. Biochem Biophys Res Commun　129：396-403, 1985

3) Abe Y, Minegishi T, Leung PC：Activin receptor signaling. Growth Factors　22：105-110, 2004

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5) Dixit H, Rao KL, Padmalatha V, et al：Expansion of the germline analysis for the INHA gene in Indian women with ovarian failure. Hum Reprod　21：1643-1644, 2006

6) Kosaki R, Gebbia M, Kosaki K, et al：Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet　82：70-76, 1999

7) Illingworth PJ, Groome NP, Byrd W, et al：Inhibin-B：a likely candidate for the physiologically important form of inhibin in men. J Clin Endocrinol Metab　81：1321-1325, 1996

8) Boepple PA, Hayes FJ, Dwyer AA, et al：Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function. J Clin Endocrinol Metab　93：1809-1814, 2008

9) Anawalt BD, Bebb RA, Matsumoto AM, et al：Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab　81：3341-3345, 1996

10) Groome NP, Illingworth PJ, O'Brien M, et al：Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab　81：1401-1405, 1996

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13) Tinkanen H, Bläuer M, Laippala P, et al：Correlation between serum inhibin B and other indicators of the ovarian function. Eur J Obstet Gynecol Reprod Biol　94：109-113, 2001

14) Klein NA, Illingworth PJ, Groome NP, et al：Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women：a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab　81：2742-2745, 1996

15) Burger HG, Hale GE, Robertson DM, et al：A review of hormonal changes during the menopausal transition：focus on findings from the Melbourne Women's Midlife Health Project. Hum Reprod Update　13：559-565, 2007

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17) Abe Y, Hasegawa Y, Miyamoto K, et al：High concentrations of plasma immunoreactive inhibin during normal pregnancy in women. J Clin Endocrinol Metab　71：133-137, 1990

18) Yohkaichiya T, Fukaya T, Hoshiai H, et al：Inhibin：a new circulating marker of hydatidiform mole? BMJ　298：1684-1686, 1989

19) Muttukrishna S, Knight PG, Groome NP, et al：Activin A and inhibin A as possible endocrine markers for pre-eclampsia. Lancet　349：1285-1288, 1997

20) Wald NJ, Huttly WJ, Hackshaw AK：Antenatal screening for Down's syndrome with the quadruple test. Lancet　361：835-836, 2003

21) Michel U, Ebert S, Phillips D, et al：Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia. Eur J Endocrinol　148：559-564, 2003

22) Jones KL, Mansell A, Patella S, et al：Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc Natl Acad Sci USA　104：16239-16244, 2007