臨床検査52巻3号

2008年03月発行

今月の主題 アルツハイマー病の最近の進歩 総論

脳アミロイドアンギオパチーとアルツハイマー病

著者： 浜口毅¹ 山田正仁¹

所属機関： ¹金沢大学大学院医学系研究科脳病態医学講座脳老化・神経病態学(神経内科)

ページ範囲：P.266 - P.272

　アルツハイマー病(AD)と同じアミロイドβ蛋白(Aβ)が脳血管に沈着するAβ型脳アミロイドアンギオパチー(cerebral amyloid angiopathy；CAA)について概説した．孤発性Aβ型CAAは60歳以上の約半数にみられ，AD患者の80～90%にみられる．遺伝性Aβ型CAAはアミロイド前駆体蛋白遺伝子変異を伴い，家族性ADの中にも高度のCAAを伴う例がある．CAAは加齢，ADと密接に関連し，脳内出血等の脳血管障害の原因となる．ADモデルに対するAβ免疫療法により脳出血が誘発されることが報告され，CAAの診断・治療法の開発はますます重要となってきている．

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