臨床検査54巻10号

2010年10月発行

今月の主題 ファーマコゲノミクス 各論

ファーマコゲノミクスを活用した関節リウマチの個別化医療

著者： 谷口敦夫¹

所属機関： ¹東京女子医科大学附属膠原病リウマチ痛風センター

ページ範囲：P.1158 - P.1162

　関節リウマチは多発関節炎が寛解と増悪を繰り返す疾患で，多く場合疾患活動性が持続し，関節が徐々に破壊される．治療の中心は薬物療法であり，最も重要なものが疾患修飾性抗リウマチ薬(DMARD)である．しかし，その効果や副作用発現には個体差が大きい．DMARDの薬効を予測する手段としてファーマコゲノミクスが注目されている．筆者らはmethotrexateやsulfasalazineについて検討を進めているが，生物学的製剤にも薬理遺伝学的アプローチが期待される．

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