臨床検査54巻13号

2010年12月発行

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今月の主題 遺伝子検査の最近の展開－ヒトゲノム多様性と医療応用 各論

肺癌の遺伝子検査

著者： 福原達朗¹ 井上彰¹ 貫和敏博¹

所属機関： ¹東北大学病院呼吸器内科

ページ範囲：P.1649 - P.1654

　肺癌は依然として日本における最も死亡者数の多い悪性腫瘍である．上皮増殖因子受容体(EGFR)の遺伝子変異陽性の肺癌に対して，EGFR阻害剤であるゲフィチニブ，エルロチニブの治療効果が明らかとなりつつある．特に最近日本より第3相臨床試験の結果が相次いで報告され，新たなエビデンスが築かれた．新規融合遺伝子EML4-ALKは肺癌で発見され，ALK阻害剤は新たな分子標的治療の手段となる可能性がある．このように肺癌に対しての個別化治療への研究と臨床応用が少しずつ進められている．

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