臨床検査55巻1号

2011年01月発行

今月の主題 -ミクログロブリン－その多様な病因，病態と検査アプローチ 総論

β₂-ミクログロブリンによる腫瘍細胞増殖とその制御

著者： 野村威雄¹ 三股浩光¹

所属機関： ¹大分大学医学部腎泌尿器外科

ページ範囲：P.27 - P.35

β₂-ミクログロブリン(β₂-m)はMHC class Iα鎖の一部であり，癌細胞増殖を刺激し，特に骨転移を誘導する増殖調節因子である可能性が報告されている．また種々の癌種において，血中または尿中β₂-mが独立した予後因子あるいは悪性度を規定するバイオマーカーとしても知られている．ある種の固形癌や血液腫瘍においては，特異的な抗β₂-m中和抗体による抗腫瘍効果を認め，正常細胞への毒性は低いことが報告されている．これらの知見は，癌治療においてβ₂-mが新たな治療標的となる可能性を示唆している．本稿では，癌細胞におけるβ₂-mの刺激伝達物質としての役割と骨転移形成への関与について概説する．

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