臨床検査55巻2号

2011年02月発行

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今月の主題 腸内細菌叢 各論 〈腸内細菌叢と疾患〉

アレルギー疾患

著者： 岩田敏¹

所属機関： ¹慶應義塾大学医学部感染制御センター

ページ範囲：P.143 - P.148

アレルギー疾患の原因として，ヘルパーT細胞であるTh1とTh2のバランスがTh2に傾き，Th2型サイトカインが増加して，IgEが産生される機序が考えられている．腸内細菌叢の形成が未熟な新生児や腸内細菌叢が形成されていない無菌動物の免疫系はTh2に傾いており，Th1/Th2の適切なバランスの発達には，腸内細菌叢の形成による経口免疫寛容が重要な役割を果たしている．この機序を利用して，プロバイオティクスのアレルギー疾患に対する効果が検討されている．

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