icon fsr

雑誌詳細

文献概要

今月の主題 腸内細菌叢 話題

抗菌薬と腸内細菌叢

著者: 大毛宏喜1

所属機関: 1広島大学病院感染症科

ページ範囲:P.173 - P.176

1. はじめに

 抗菌薬が腸内細菌に及ぼす影響が問題となっている.NDM-1(New Delhi metallo-β-lactamase 1)産生菌は,インド国内で抗菌薬が処方箋なしに購入できることが一因とされる1).このような原因で,有効な抗菌薬が存在しない耐性菌が生まれるのは脅威と言える.膨大な数の細菌から構成される大腸腸内細菌叢は,それほどまでに抗菌薬に対してデリケートなのだろうか.また,耐性菌予防の観点から対策はあるのだろうか.

参考文献

1) Kumarasamy KK, Toleman MA, Walsh TR, et al:Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK:a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597-602,2010
2) Nichols RL, Condon RE, Gorbach SL, et al:Efficacy of preoperative antimicrobial preparation of the bowel. Ann Surg 176:227-232,1972
3) Bratzler DW, Hunt DR:The surgical infection prevention and surgical care improvement projects:national initiatives to improve outcomes for patients having surgery. Clin Infect Dis 43:322-330,2006
4) Snydman DR, Jacobus NV, McDermott LA, et al:National survey on the susceptibility of Bacteroides fragilis group:report and analysis of trends in the United States from 1997 to 2004. Antimicrob Agents Chemother 51:1649-1655,2007
5) Itani KM, Wilson SE, Awad SS, et al:Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. N Engl J Med 355:2640-2651,2006
6) 赤木真治,竹末芳生,横山隆:消化器外科手術におけるcefazolinの腸内細菌叢への影響.日本消化器外科学会雑誌 32:255-259,2000
7) 竹末芳生,横山隆,赤木真治:消化器外科手術におけるflomoxefの腸内細菌叢への影響.日本化学療法学会雑誌 47:74-79,1999
8) Costelloe C, Metcalfe C, Lovering A, et al:Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients:systematic review and meta-analysis. BMJ 340:c2096,2010
9) Seppala H, Klaukka T, Vuopio-Varkila J, et al:The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance. N Engl J Med 337:441-446,1997
10) Enne VI:Reducing antimicrobial resistance in the community by restricting prescribing:can it be done? J Antimicrob Chemother 65:179-182,2010
11) Johnson JR, Johnston B, Clabots C, et al:Escherichia coli sequence type ST131 as the major cause of serious multidrug-resistant E. coli infections in the United States. Clin Infect Dis 51:286-294,2010
12) Peirano G, Pitout JD:Molecular epidemiology of Escherichia coli producing CTX-M beta-lactamases:the worldwide emergence of clone ST131 O25:H4. Int J Antimicrob Agents 35:316-321,2010
13) Dhanji H, Murphy NM, Doumith M, et al:Cephalosporin resistance mechanisms in Escherichia coli isolated from raw chicken imported into the UK. J Antimicrob Chemother 65:2534-2537,2010

掲載雑誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?