文献詳細
文献概要
今月の主題 癌幹細胞と検査医学 各論
急性白血病
著者: 中島秀明1
所属機関: 1慶應義塾大学医学部血液内科
ページ範囲:P.464 - P.470
文献購入ページに移動近年の幹細胞研究やゲノム研究の進歩により,白血病幹細胞の正体が次第に明らかとなってきた.白血病幹細胞は正常造血幹細胞に類似した表現型をもち,極めてよく似た分子メカニズムにより自己複製などの幹細胞機能が維持されている.しかしながら白血病幹細胞特異的な治療を開発するため,正常造血幹細胞と白血病幹細胞の細胞表面マーカーやシグナル伝達機構のわずかな違いを見いだし,モノクローナル抗体や低分子化合物による治療につなげようとする試みが行われている.
参考文献
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