icon fsr

文献詳細

雑誌文献

臨床検査55巻5号

2011年05月発行

文献概要

今月の主題 癌幹細胞と検査医学 各論

膵癌

著者: 小池博之1 中田晋1 谷口英樹1

所属機関: 1横浜市立大学大学院医学研究科臓器再生医学

ページ範囲:P.495 - P.499

文献購入ページに移動
膵癌は既存の治療法に強い抵抗性を示し,極めて予後が悪い.近年,膵癌中に幹細胞の性質をもつ,いわゆる癌幹細胞が少数存在し,治療抵抗性に寄与しているというモデルが提唱されている.膵癌の治療抵抗性にかかわる膵癌幹細胞の同定は,有効な膵癌の治療法を開発するうえで重要と考えられる.

参考文献

1) Li C, Heidt DG, Dalerba P, et al:Identification of pancreatic cancer stem cells. Cancer Res 67:1030-1037,2007
2) Hermann PC, Huber SL, Herrler T, et al:Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313-323,2007
3) Hong SP, Wen J, Bang S, et al:CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells. Int J Cancer 125:2323-2331,2009
4) Mueller MT, Hermann PC, Witthauer J, et al:Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer. Gastroenterology 137:1102-1113,2009
5) Shah AN, Summy JM, Zhang J, et al:Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol 14:3629-3637,2007
6) Feldmann G, Dhara S, Fendrich V, et al:Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases:a new paradigm for combination therapy in solid cancers. Cancer Res 67:2187-2196,2007
7) Jimeno A, Feldmann G, Suarez-Gauthier A, et al:A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol Cancer Ther 8:310-314,2009
8) Rasheed ZA, Yang J, Wang Q, et al:Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst 102:340-351,2010
9) Kondo T, Setoguchi T, Taga T:Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 101:781-786,2004
10) Wang YH, Li F, Luo B, et al:A side population of cells from a human pancreatic carcinoma cell line harbors cancer stem cell characteristics. Neoplasma 56:371-378,2009
11) Dylla SJ, Beviglia L, Palk IK, et al:Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 3:e2428,2008
progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. Cancer Res 60:4403-4411,2000
13) Soeda A, Park M, Lee D, et al:Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α. Oncogene 28:3949-3959,2009
14) Kaanders JH, Wijffels KI, Marres HA, et al:Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res 62:7066-7074,2002
15) Bao S, Wu Q, McLendon RE, et al:Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760,2006
breast cancer-initiating cells to radiation. J Natl Cancer Inst 98:1777-1785,2006

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?