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文献概要

今月の主題 IgG4関連疾患 総論

IgG4関連疾患の臓器病変と病理

著者: 全陽1 中沼安二2

所属機関: 1 2金沢大学大学院形態機能病理学

ページ範囲:P.748 - P.752

IgG4関連疾患は,いずれの臓器に発生しても基本的な病理学的所見は共通しているが,いくつか臓器特異的な変化も知られている.また,最近の解析により,頭頸部病変で女性の比率が高いこと,腎病変が単独で発生することは稀であることなど,臓器別の臨床的特徴も明らかとなりつつある.本稿では,IgG4関連疾患の病理学的特徴と,臓器特異的変化について,総論的・横断的に解説する.

参考文献

1) Hamano H, Kawa S, Horiuchi A, et al : High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 344:732-738,2001
2) Hamano H, Kawa S, Ochi Y, et al : Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet 359:1403-1404,2002
3) Zen Y, Harada K, Sasaki M, et al : IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis : do they belong to a spectrum of sclerosing pancreatitis? Am J Surg Pathol 28:1193-1203,2004
4) Kawaguchi K, Koike M, Tsuruta K, et al : Lymphoplasmacytic sclerosing pancreatitis with cholangitis : a variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol 22:387-395,1991
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8) Zen Y, Kasahara Y, Horita K, et al : Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level : histologic similarity to sclerosing pancreatitis. Am J Surg Pathol 29:275-278,2005
9) Zen Y, Fujii T, Sato Y, et al : Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease. Mod Pathol 20:884-894,2007
10) Zen Y, Nakanuma Y : IgG4-related disease : a cross-sectional study of 114 cases. Am J Surg Pathol 34:1812-1819,2010
11) Okazaki K : Autoimmune pancreatitis : etiology, pathogenesis, clinical findings and treatment. The Japanese experience. JOP 6:89-96,2005
12) Zen Y, Fujii T, Harada K, et al : Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology 45:1538-1546,2007
13) Miyoshi H, Uchida K, Taniguchi T, et al : Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis. Pancreas 36:133-140,2008

掲載雑誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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