臨床検査55巻9号

2011年09月発行

今月の主題 RNAの解析 各論 〈病態疾患と動態解析〉

異常なmRNAを分解する仕組み

著者： 山下暁朗¹²

所属機関： ¹横浜市立大学大学院医学部医学科 ²横浜市立大学先端医科学研究センター

ページ範囲：P.885 - P.891

真核生物には，転写後のmRNAの品質を管理する様々な機構が存在し，遺伝子発現の正確性が保証されている．このmRNAの品質管理システムの分子機構の解明が進められており，mRNA品質管理機構により排除されている変異遺伝子産物をDNAマイクロアレイや次世代シークエンサーといった様々な新しい手法を用いて同定することも可能となってきている．さらに，品質管理機構の分子メカニズムの理解をもとに，その阻害剤の開発も行われており，患者個人に合わせたオーナーメード医療の実現に寄与していくことが期待される．

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