臨床検査55巻9号

2011年09月発行

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今月の主題 RNAの解析 各論 〈病態疾患と動態解析〉

スプライシング異常から解析する統合失調症

著者： 眞部孝幸¹ 前田明¹

所属機関： ¹藤田保健衛生大学総合医科学研究所遺伝子発現機構学研究部門

ページ範囲：P.893 - P.899

神経細胞やグリア細胞などの神経系細胞の遺伝子発現調節に，選択的スプライシングが重要な役割を演じている．それゆえに，この調節機構の破綻は重篤な発達障害や疾患発現の引き金となる．近年多くの神経変性疾患や精神疾患において種々の遺伝子のスプライシング異常が報告されている．本稿では，最近急速に報告され始めた統合失調症における選択的スプライシングの異常に焦点を当て，最新の情報を紹介しつつ，異常スプライシングを標的とした診断・治療への可能性について解説する．

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