臨床検査56巻10号

2012年10月発行

今月の主題 鉄代謝のバイオマーカー 各論 〈検査指標〉

非トランスフェリン結合鉄

著者： 佐々木勝則¹ 生田克哉² 鳥本悦宏³ 高後裕²

所属機関： ¹旭川医科大学消化管再生修復医学講座 ²旭川医科大学消化器・血液腫瘍制御内科学分野 ³旭川医科大学病院腫瘍センター

ページ範囲：P.1070 - P.1082

血液中のトランスフェリンに結合しないフリーな鉄を総称して非トランスフェリン結合鉄(NTBI)と呼ぶ．このNTBIは生体にとって有害となる鉄の存在形式で，その測定は臨床的に鉄が生体に及ぼす影響をとらえるうえで重要と考えられている．筆者らはnon-metal HPLCを用いた安定かつ高感度なNTBI測定法を確立し，より正確な健常人の血清NTBI値を算出することに成功した．これを基準に，体内の鉄動態を把握する新しい指標としての血清NTBI値の可能性について，これまでに報告された病態とNTBIとの関係も含めて考察する．

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