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臨床検査57巻5号

2013年05月発行

文献概要

今月の特集2 ADAMTS13と臨床検査

ADAMTS13と肝細胞癌

著者: 池田均1

所属機関: 1東京大学大学院医学系研究科臨床病態検査医学

ページ範囲:P.563 - P.566

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■ADAMTS13は肝臓の星細胞により特異的に産生される.

■動物の肝障害モデルにおいて,血中ADAMTS13活性は星細胞による産生に強く規定される.

■ウイルス性慢性肝障害例で血中ADAMTS13活性が高い症例ほど,後の肝細胞癌発症頻度が高かった.

参考文献

1)Soejima K, Mimura N, Hirashima M, et al:A novel human metalloprotease synthesized in the liver and secreted into the blood:possibly, the von Willebrand factor-cleaving protease? J Biochem 130:475-480,2001
2)Zhou W, Inada M, Lee TP, et al:ADAMTS13 is expressed in hepatic stellate cells. Lab Invest 85:780-788,2005
3)Uemura M, Tatsumi K, Matsumoto M, et al:Localization of ADAMTS13 to the stellate cells of human liver. Blood 106:922-924,2005
4)Kume Y, Ikeda H, Inoue M, et al:Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats. FEBS Lett 581:1631-1634,2007
5)Watanabe N, Ikeda H, Kume Y, et al:Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis. Thromb Haemost 102:389-396,2009
6)Mannucci PM, Canciani MT, Forza I, et al:Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood 98:2730-2735,2001
7)Feys HB, Canciani MT, Peyvandi F, et al:ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis. Br J Haematol 138:534-540,2007
8)Uemura M, Fujimura Y, Matsumoto M, et al:Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis. Thromb Haemost 99:1019-1029,2008
9)Lisman T, Bongers TN, Adelmeijer J, et al:Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 44:53-61,2006
10)Ikeda H, Tateishi R, Enooku K, et al:Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C. Cancer Epidemiol Biomarkers Prev 20:2204-2211,2011

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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