臨床検査58巻4号

2014年04月発行

今月の特集2 話題の感染症2014

鳥インフルエンザA（H7N9）

著者： 菅谷憲夫¹²

所属機関： ¹神奈川県警友会けいゆう病院　小児科 ²慶應義塾大学　医学部

ページ範囲：P.474 - P.478

●鳥インフルエンザA（H7N9）は，パンデミックを起こす可能性が高い．

●H7N9は弱毒ウイルスであるが，人が感染すると重症化する．

●H7N9は，ノイラミニダーゼ阻害薬に感受性があるが，すでに耐性ウイルスが出現した．

●安全性の高いH7N9ワクチンの開発が望まれる．

参考文献

1）Sugaya N, Shinjoh M, Mitamura K, et al：Very low pandemic influenza A (H1N1) 2009 mortality associated with early neuraminidase inhibitor treatment in Japan : analysis of 1000 hospitalized children. J Infect　63：288-294，2011

2）Sugaya N：Widespread use of neuraminidase inhibitors in Japan. J Infect Chemother　17：595-601，2011

3）Zhang Q, Shi J, Deng G, et al：H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science　341：410-414，2013

4）Ip DK, Liao Q, Wu P, et al：Detection of mild to moderate influenza A/H7N9 infection by China’s national sentinel surveillance system for influenza-like illness : case series. BMJ　346：f3693，2013

5）Yang F, Wang J, Jiang L：A fatal case caused by novel H7N9 avian influenza A virus in China. Emerg Microbes Infect　2：e19，2013

6）Hu Y, Lu S, Song Z, et al：Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet　381：2273-2279，2013

7）Yen HL, McKimm-Breschkin JL, Choy KT, et al：Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population. MBio　4：e00396-13，2013

8）South East Asia Infectious Disease Clinical Research Network：Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial. BMJ　346：f3039，2013