臨床検査58巻6号

2014年06月発行

今月の特集1 液状化検体細胞診（LBC）にはどんなメリットがあるか

LBCの利点と問題点

著者： 南口早智子¹

所属機関： ¹京都大学医学部附属病院　病理診断科

ページ範囲：P.670 - P.676

●液状化検体細胞診（LBC）の導入で，不適正検体の減少，TAT（turn around time）の短縮を確認した．

●保存検体を免疫染色や遺伝子検査などの補助的検査に応用できる．

●コストの問題は依然として継続している．

●従来法との違いを認識し，ある程度の習熟が必要である．

参考文献

1）Akamatsu S, Kodama S, Himeji Y, et al：A comparison of liquid-based cytology with conventional cytology in cervical cancer screening. Acta Cytol　56：370-374，2012

2）Singh M, Mockler D, Akalin A, et al：Immunocytochemical colocalization of P16 (INK4a) and Ki-67 predicts CIN2/3 and AIS/adenocarcinoma. Cancer Cytopathol　120：26-34，2012

3）Siddiqui MT, Cohen C, Nassar A：Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid CaptureⅡHPV DNA testing. Am J Clin Pathol　130：765-770，2008

4）American College of Obstetricians and Gynecologists. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Number 61, April 2005. Human papillomavirus. Obstet Gynecol　105：905-918，2005

5）Clavel C, Masure M, Bory JP, et al：Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women. Br J Cancer　84：1616-1623，2001

6）Hutchinson ML, Zahniser DJ, Sherman ME, et al：Utility of liquid-based cytology for cervical carcinoma screening: results of a population-based study conducted in a region of Costa Rica with a high incidence of cervical carcinoma. Cancer　87：48-55，1999

7）Schledermann D, Ejersbo D, Hoelund B：Improvement of diagnostic accuracy and screening conditions with liquid-based cytology. Diagn Cytopathol　34：780-785，2006

8）Strander B, Andersson-Ellström A, Milsom I, et al：Liquid-based cytology versus conventional Papanicolaou smear in an organized screening program: a prospective randomized study. Cancer　111：285-291，2007

9）Arbyn M, Bergeron C, Klinkhamer P, et al：Liquid compared with conventional cervical cytology: a systematic review and meta-analysis. Obstet Gynecol　111：167-177，2008

10）Confortini M, Bergeron C, Desai M, et al：Accuracy of liquid-based cytology: comparison of the results obtained within a randomized controlled trial (the New Technologies for Cervical Cancer Screening Study) and an external group of experts. Cancer Cytopathol　118：203-208，2010

11）Sigurdsson K：Is a liquid-based cytology more sensitive than a conventional Pap smear? Cytopathology　24：254-263，2013