臨床検査59巻2号

2015年02月発行

今月の特集1 動脈硬化症の最先端

ゲノム・エピゲノムからみた動脈硬化症

著者： 稲垣毅¹ 谷村恭子¹² 酒井寿郎¹

所属機関： ¹東京大学　先端科学技術研究センター代謝医学分野 ²日本医科大学　糖尿病内分泌代謝

ページ範囲：P.110 - P.118

●動脈硬化症の発症にはゲノム異常やエピゲノム制御機構が関与する．

●家族性高コレステロール血症（FH）をはじめとする遺伝子異常のほかに，DNAメチル化やヒストン修飾調節，microRNA（miRNA）を介した動脈硬化症の発症機構が明らかになってきた．

●ゲノムシークエンサーの進化やビックデータ解析速度の上昇などから，ゲノム・エピゲノム検査がより広く行われることが予想される．

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