臨床検査60巻7号

2016年07月発行

今月の特集2 百日咳，いま知っておきたいこと

百日咳の疫学—国内外の状況

著者： 神谷元¹

所属機関： ¹国立感染症研究所感染症疫学センター

ページ範囲：P.730 - P.735

Point

●百日咳は，世界的にみてもワクチンでは十分にコントロールできていない．

●海外ではサーベイランスが充実しており，重症化しやすい乳児を守るための対策を実施している．

●国内の百日咳サーベイランスには多くの制約があり，正確な疾病負荷を把握しきれていない．

●わが国の百日咳対策として，追加接種や，成人へ接種可能なワクチンの認可を検討する必要性がある．

参考文献

1）World Health Organization：The Expanded Programme on Immunization, 2013（http://www.who.int/immunization/programmes_systems/supply_chain/benefits_of_immunization/en/）

2）Centers for Disease Control and Prevention (CDC)：Pertussis. In: Epidemiology and Prevention of Vaccine-Preventable Diseases, 12th ed, CDC，pp215-232，2012

3）Centers for Disease Control and Prevention (CDC)：National notifiable diseases surveillance system and supplemental pertussis surveillance system and 1922-1949, passive reports to the public health service

4）Centers for Disease Control and Prevention (CDC)：Recommended childhood and adolescent immunization schedule---United States, 2006. MMWR Morb Mortal Wkly Rep　54：Q1-Q4，2006

5）Cherry JD：The epidemiology of pertussis: a comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection. Pediatrics　115：1422-1427，2005

6）von König CH, Halperin S, Riffelmann M, et al：Pertussis of adults and infants. Lancet Infect Dis　2：744-750，2002

7）Broder KR, Cortese MM, Iskander JK, et al：Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep　55（RR-3）：1-34，2006

8）Centers for Disease Control and Prevention (CDC)：Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine from the Advisory Committee on Immunization Practices, 2010. MMWR Morb Mortal Wkly Rep　60：13-15，2011

9）Centers for Disease Control and Prevention (CDC)：FDA approval of expanded age indication for a tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine. MMWR Morb Mortal Wkly Rep　60：1279-1280，2011

10）Centers for Disease Control and Prevention (CDC)：Pertussis epidemic--Washington, 2012. MMWR Morb Mortal Wkly Rep　61：517-522，2012

11）Acosta AM, DeBolt C, Tasslimi A, et al：Tdap vaccine effectiveness in adolescents during the 2012 Washington State pertussis epidemic. Pediatrics　135：981-989，2015

12）Kamiya H, Cho BH, Messonnier ML, et al：Impact and cost-effectiveness of a second tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine dose to prevent pertussis in the United States. Vaccine　34：1832-1838，2016

13）Bisgard KM, Pascual FB, Ehresmann KR, et al：Infant pertussis: who was the source? Pediatr Infect Dis J　23：985-989，2004

14）Centers for Disease Control and Prevention (CDC)：Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged ＜12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. MMWR Morb Mortal Wkly Rep　60：1424-1426，2011

15）Centers for Disease Control and Prevention (CDC)：Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women--Advisory Committee on Immunization Practices (ACIP), 2012. MMWR Morb Mortal Wkly Rep　62：131-135，2013

16）Amirthalingam G, Andrews N, Campbell H, et al：Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet　384：1521-1528，2014

17）Walls T, Graham P, Petousis-Harris H, et al：Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study. BMJ Open　6：e009536，2016

18）国立感染症研究所：百日せきワクチンに関するファクトシート　平成22年7月7日版，2010

19）国立感染症研究所：感染症発生動向調査　感染症週報　2014年第32週（第32号），2014

20）安藤由香，大平文人，神谷元，他：宮崎県における百日咳菌とBordetella holmesiiの同時流行．IASR　33：329-330，2012

21）額賀俊介，小川直子：新潟県の中学校における百日咳集団発生事例．IASR　36：142-143，2015