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雑誌文献

臨床検査62巻5号

2018年05月発行

文献概要

今月の特集2 不妊・不育症医療の最前線

不育症の診断と治療

著者: 杉浦真弓12

所属機関: 1名古屋市立大学大学院医学研究科産科婦人科学 2名古屋市立大学不育症研究センター

ページ範囲:P.642 - P.648

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●不育症(RPL)の4大原因は,抗リン脂質抗体症候群(APS),子宮奇形,夫婦染色体均衡型転座,胎児(胎芽)染色体数的異常である.

●2回以上の早期流産,1回以上の子宮内胎児死亡,妊娠高血圧腎症や胎盤機能不全による34週未満の早産のときに,APSを疑う.

●2種類のループスアンチコアグラント(LA)として,リン脂質中和法,希釈ラッセル蛇毒法の両方とも測定する.

参考文献

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2)杉浦真弓:エビデンスに基づいた不育症・習慣流産の診療,金芳堂,2017
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18)Asano E, Ebara T, Yamada-Namikawa C, et al:Genotyping analysis for the 46 C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss. PLoS One 9:e114452,2014
19)Kaandorp SP, Goddijn M, van der Post JA, et al:Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 362:1586-1596,2010
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21)Sugiura-Ogasawara M, Atsumi T, Yamada H, et al:Real-world practice of obstetricians in respect of assays for antiphospholipid antibodies. Mod Rheumatol 25:883-887,2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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