臨床検査66巻12号

2022年12月発行

今月の特集 クローン性造血に関する知見と課題

クローン性造血とは

著者： 國本博義¹ 中島秀明¹

所属機関： ¹横浜市立大学医学部血液・免疫・感染症内科学

ページ範囲：P.1370 - P.1378

Point

●クローン性造血はX染色体不活化パターンの解析によってその存在が推測された．また，遺伝子変異と体細胞モザイクの発見によって，その基盤が確立した．

●クローン性造血は血液がんとの関連をはじめ，心血管疾患・脳卒中・固形がんなどの非血液疾患や既往生活歴・環境因子との深い相関も明らかになりつつある．

●クローン性造血と関連病態との因果関係についてはいまだ明らかにされていない点も多い．今後の研究の進展による全体像の解明が待たれる．

参考文献

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