臨床検査66巻12号

2022年12月発行

今月の特集 クローン性造血に関する知見と課題

クローン性造血と心血管疾患

著者： 福本義弘¹

所属機関： ¹久留米大学医学部内科学講座心臓・血管内科部門

ページ範囲：P.1413 - P.1421

Point

●未確定の潜在能をもつクローン性造血（CHIP）は加齢とともに増加し，インターロイキン（IL）-1βやIL-6を介して動脈硬化，心不全，血栓症などの発症リスクを上げる．

●骨髄増殖性腫瘍患者において，腫瘍変化をきたした骨髄細胞が末梢血中を循環し，心血管病を惹起する．

●CHIPのうち，高頻度で認められるのがDNMT3A，TET2，ASXL1，JAK2である．

参考文献

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