臨床検査67巻3号

2023年03月発行

今月の特集2 臨床検査で患者を救え！—知っておいてほしい疾患

Extreme delta brush

著者： 本多正幸¹² 池田昭夫²³

所属機関： ¹東京都立神経病院脳神経内科 ²京都大学大学院医学研究科てんかん・運動異常生理学講座 ³京都大学大学院医学研究科臨床神経学

ページ範囲：P.236 - P.244

症例の背景^1）

　患者は19歳，右利きの女性．

参考文献

1）池田昭夫，人見健文，松本理器，他：急性抗NMDA受容体脳炎の脳波．最新医　64：1578-1584，2009

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3）Gleichman AJ, Spruce LA, Dalmau J, et al：Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain. J Neurosci　32：11082-11094，2012

4）Bien CG, Vincent A, Barnett MH, et al：Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain　135：1622-1638，2012

5）Titulaer MJ, McCracken L, Gabilondo I, et al：Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol　12：157-165，2013

6）Graus F, Titulaer MJ, Balu R, et al：A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol　15：391-404，2016

7）Dalmau J, Armangué T, Planagumà J, et al：An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol　18：1045-1057，2019

8）de Bruijn MAAM, van Sonderen A, van Coevorden-Hameete MH, et al：Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis. Neurology　92：e2185-e2196，2019

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，2022

12）本多正幸，池田昭夫：目でみるてんかん：Extreme delta brush（脳波像について）．Epilepsy　15：6-8，2021

13）Ikeda A, Matsui M, Hase Y, et al：“Burst and slow complexes” in nonconvulsive epileptic status. Epileptic Disord　8：61-64，2006

14）Schmitt SE, Pargeon K, Frechette ES, et al：Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology　79：1094-1100，2012

15）Theroux LM, Goodkin HP, Heinan KC, et al：Extreme delta brush and distinctive imaging in a pediatric patient with autoimmune GFAP astrocytopathy. Mult Scler Relat Disord　26：121-123，2018

16）Hirsch LJ, Fong MWK, Leitinger M, et al：American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology: 2021 Version. J Clin Neurophysiol　38：1-29，2021

17）da Silva-Júnior FP, Castro LH, Andrade JQ, et al：Serial and prolonged EEG monitoring in anti-N-Methyl-D-Aspartate receptor encephalitis. Clin Neurophysiol　125：1541-1544，2014

18）Chanson E, Bicilli É, Lauxerois M, et al：Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus?. Neurophysiol Clin　46：17-25，2016

19）Ueda J, Kawamoto M, Hikiami R, et al：Serial EEG findings in anti-NMDA receptor encephalitis: correlation between clinical course and EEG. Epileptic Disord　19：465-470，2017

20）Dalmau J, Lancaster E, Martinez-Hernandez E, et al：Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol　10：63-74，2011

21）Heine J, Kopp UA, Klag J, et al：Long-Term Cognitive Outcome in Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Ann Neurol　90：949-961，2021

22）Hirose S, Hara M, Kamei S, et al： Characteristics of clinical relapses and patient-oriented long-term outcomes of patients with anti-N-methyl-D-aspartate receptor encephalitis. J Neurol　269：2486-2492，2022